Kucan as Kane, congratulating or taunting the players as they progress in Kane's Challenge. Also included in this game mode are all-new, high-definition video sequences featuring Joseph D. Similar to the Generals Challenge mode in Zero Hour, the player chooses one of the nine factions, and is pitted against all armies spanning ten challenges referred to as 'The Gauntlet' in-game. Kane's Challenge is exclusive to the Xbox 360 version of Kane's Wrath, replacing Global Conquest Mode.

Combat in this mode occurs whenever two opposing forces collide on the world map the battle can either be played traditionally (as a standard real-time C&C game) or be automatically resolved by the computer using the forces' relative strengths. Instead of the traditional Command & Conquer RTS gameplay, the mode uses a turn-based system where the player issues higher-level orders such as 'build a base here' (to have the computer automatically build a base with preset structures) or 'upgrade this base' (to have the computer automatically perform multiple structure upgrades on a base) the orders execute at the end of a turn and the other sides then get theirs. Kane's Wrath features a ' Risk-like' gameplay mode called 'Global Conquest', where players build and control their forces from a strategic, global level with the goal of either destroying all enemies or completing their side's alternate victory objective.

Legion command and conquer